Buy Praziquantel ((FULL))
Keep your pets healthy and comfortable with praziquantel to treat and control tapeworms and other parasitic worms. At Revival Animal Health, we offer a selection of praziquantel for dogs and other animals. We make caring for your pets easier with safe praziquantel dewormers and expert advice.
PetArmor 7 Way De-Wormer (pyrantel pamoate/praziquantel) treats and controls seven species of worms: two tapeworms (Dipylidium caninum and Taenia pisiformis), two species of roundworms (Toxocara canis and Toxascaris leonina) and three species of hookworms (Ancylostoma caninum, Ancylostoma braziliense and Uncinaria stenocephala). This broad spectrum de-wormer comes in flavored chewable tablets, making it easy and convenient to give to your dog.
Praziquantel prescription medication is sometimes marketed under the brand name Biltricide and is used to treat different types of parasitic infections such as schistosomiasis. Praziquantel, like mebendazole (Emverm), belongs to a class of medications known as anthelmintic drugs. The praziquantel dosage sometimes prescribed is praziquantel 20 mg / kg three times per day as a one day treatment although cure rates can be low at times. Ultimately, however, the actual praziquantel regimen used depends on the health needs of the patient and the judgement of the prescribing medical provider. Praziquantel is moderately expensive, costing approximately $30 per praziquantel 600mg tablet at many pharmacies in the United States. Praziquantel coupons are sometimes available online or through other sources and some insurance plans may help cover costs associated with a praziquantel prescription for humans. Praziquantel is generally available as praziquantel 600 mg tablets which are white to orange in color.
Praziquantel requires a prescription to be dispensed by a pharmacy in the United States. For this reason, praziquantel OTC is not available and, in order to buy praziquantel online, one must first obtain a praziquantel prescription after consulting a licensed medical provider. People who might need a praziquantel prescription, including praziquantel 600 mg tablets, can use Push Health to connect with a medical provider who can prescribe praziquantel for humans, including praziquantel 600 mg tablets, when appropriate to do so.
Praziquantel prescription medication can cause side effects when used and concerns should be discussed with a qualified medical provider before use. Side effects that may occur from praziquantel medication use include headache, dizziness, fatigue, and urticaria. Praziquantel tablets and alcohol should not be used together. People with an allergy to praziquantel or similar medications should not use praziquantel medication.
We have identified two resolution approaches toward the production of praziquantel as a single enantiomer. One approach starts with commercially available praziquantel and involves a hydrolysis to an intermediate amine, which is resolved with a derivative of tartaric acid. This method was discovered through an open collaboration on the internet. The second method, identified by a contract research organisation, employs a different intermediate that may be resolved with tartaric acid itself.
Both resolution procedures identified show promise for the large-scale, economically viable production of praziquantel as a single enantiomer for a low price. Additionally, they may be employed by laboratories for the production of smaller amounts of enantiopure drug for research purposes that should be useful in, for example, elucidation of the drug's mechanism of action.
A coordination website was created on which was posted the problem of the preparation of praziquantel as a single enantiomer. While suggestions were received, input was initially low. In mid-2008 the project was funded by a government/NGO consortium. The resulting raw experimental data were posted in full to an open, online electronic lab notebook (based on the open source electronic lab notebook system, Labtrove, developed by the University of Southampton, UK. ) Periodic updates were posted on the coordination website, and the project was popularised to increase traffic (For a description of how the open science project was conducted, see the accompanying paper ).
We thank Denis Daumerie (WHO/NTD) for a gift of racemic praziquantel, Harald Sekljic (Intervet Innovation GmbH) for a gift of analytically pure samples of (R)- and (S)-PZQ and Donato Cioli (Institute of Cell Biology, Rome) for initial guidance. We thank all the many people who contributed to the open science project on The Synaptic Leap, the Custom Organic Synthesis and Process Chemistry Group at LinkedIn, the Labtrove group at the University of Southampton (particularly Professor Jeremy Frey and Andrew Milsted) and those who contributed by other means. A list of contributors is provided in the supporting information file Text S2 Contributors. An early draft of this paper was prepared collaboratively online on the following website: :PZQ_Resolution
Praziquantel comes as a tablet to take by mouth with water and a meal. It is usually taken for one day as three doses; each dose spaced 4 to 6 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take praziquantel exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Praziquantel is also sometimes used to treat certain other worm infestations, including tapeworm (a type of worm that may attach to the wall of the intestine or may move to different parts of the body). Talk to your doctor about the risks of using praziquantel to treat your condition.
The injectable form of this medication may cause moderate stinging, and it is not uncommon for animals to scratch at the injection site or cry for a moment following an injection of praziquantel. Oral praziquantel has a bitter taste and may cause nausea in some animals.
Praziquantel is not for use in animals under 4 weeks of age. This drug may interact with certain other drugs or supplements. It is important to disclose all medications currently being used before beginning treatment with praziquantel.
In dogs, the typical dose of praziquantel injectable is 0.2 ml of the 56.8 mg/ml product per 5 lbs as a single dose. The maximum injectable dose is 3 ml, and tablets are administered at 2.5 mg/lb (5 mg/kg) in a single dose. In cats, the maximum injectable dose is 0.6 ml. Tablets are dosed at 2.5 mg/lb (5 mg/kg) in a single dose.
If a dose of praziquantel is missed, it should be given right away. If it is almost time for the next dose, the missed dose should be skipped and the normal schedule resumed. In most cases, this will not be necessary, as praziquantel is typically administered in a single dose. Two doses of this medication should not be given at once.
The active ingredient used to kill tapeworms (praziquantel) is bitter and may have compromised palatability of the chew, leading to reduced compliance. Through its rapid control of fleas, NexGard SPECTRA has been shown to be 100% effective at preventing flea tapeworm infestation for a full month however, it will not kill flea tapeworms that may already be present. To control existing tapeworm infestations use ParaGard.
Infections with all major Schistosoma species can be treated with praziquantel. The timing of treatment is important since praziquantel is most effective against the adult worm and requires the presence of a mature antibody response to the parasite. For travelers, treatment should be at least 6-8 weeks after last exposure to potentially contaminated freshwater. One study has suggested an effect of praziquantel on schistosome eggs lodged in tissues. Limited evidence of parasite resistance to praziquantel has been reported based on low cure rates in recently exposed or heavily infected populations; however, widespread clinical resistance has not occurred. Thus, praziquantel remains the drug of choice for treatment of schistosomiasis. Host immune response differences may impact individual response to treatment with praziquantel. Although a single course of treatment is usually curative, the immune response in lightly infected patients may be less robust, and repeat treatment may be needed after 2 to 4 weeks to increase effectiveness. If the pre-treatment stool or urine examination was positive for schistosome eggs, follow up examination at 1 to 2 months post-treatment is suggested to help confirm successful cure.
There is a lack of safety trial data for the use of praziquantel in children less than 4 years of age or pregnant women. However, this drug has been distributed widely in mass drug administration programs and WHO now recommends that pregnant women should be treated as part of those campaigns based on extensive experience with the drug and review of the veterinary and human evidence. Similarly, WHO reports that there is growing evidence that infected children as young as 1 year old can be effectively treated with praziquantel without serious side effects; however, the drug is commonly available in the form of large, hard-to-swallow pills, which puts young children at risk for choking and other difficulties swallowing the drug.
Praziquantel is pregnancy category B. There are no adequate and well-controlled studies in pregnant women. However, the available evidence suggests no difference in adverse birth outcomes in the children of women who were accidentally treated with praziquantel during mass prevention campaigns compared with those who were not. In mass prevention campaigns for which the World Health Organization (WHO) has determined that the benefit of treatment outweighs the risk, WHO encourages the use of praziquantel in any stage of pregnancy. For individual patients in clinical settings, the risk of treatment in pregnant women who are known to have an infection needs to be balanced with the risk of disease progression in the absence of treatment. 041b061a72